Allograft mineralized bone block; A suitable substitute for bone regeneration

Allograft mineralized bone block; A suitable substitute for bone regeneration

6^th International Congress on Biomedicine

Amirhossein Tavakoli, Sara Tabatabaee, and Reza Samanipour

Introduction: According to the increasing worldwide statistics of bone defects which could have an undeniable effect on the patient’s quality of life, several investigations have been attributed to fabricate an ideal bone regenerative scaffold. Among different types of bone grafting, the clinical application of allografting have been progressed due to providing osteoconductive substitutes with similar characteristics to the native tissue without any limitations in resources. Nevertheless, there is still the risk of infection transmission and immunogenicity in this regard.

Methods: Herein, for the aim of overcoming these challenges, an allograft mineralized bone block was processed through decellularizing and lyophilizing after approving the sterility evaluations of the selected donor. The bock was evaluated using scanning electron microscopy (SEM) and image-j software.

Results: Based on the results, the final product was an interconnected porous structure with pore size ranges between 100-900 µm.

Conclusion: Therefore, it could be concluded that the prepared structure is an appropriate candidate for bone tissue regeneration.

Keywords: Allograft, Mineralized Bone Block, Bone Tissue Engineering, Regenerative Medicine