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Allograft acellular dermal matrix as a potential substitute for wound healing application

9th International Congress of Wound and Tissue Repair

Mahsa Delyanee, Reza Samanipour, Amirhossein Tavakoli, and Sara Tabatabaee

 

ABSTRACT

Wounds that do not heal can be a severe clinical complication. The extracellular matrix (ECM) is frequently defective in chronic wounds because of the relative lack of protease inhibitors, which generally regulate protease, and the inflammatory and proteolytic environment of chronic wounds, which breaks down ECM.

Alternative strategies, especially the use of acellular dermal matrixes (ADM)s, are now expanding for wound healing application to overcome the limitations, including further injury at the donor site of the patient, which is required when autograft skin is applied, and final rejection of homologous tissue for the presence of foreign cellular component. ADMs were created in an effort to take advantage of native ECM’s benefits and encourage orderly regenerative of the host tissue in several therapeutic situations.

ADM has been shown to influence wound healing through several previously identified mechanisms, including scaffolding for the formation of granulation tissue, the presence of receptors for fibroblast attachment, stimulation of angiogenesis, activity as a chemoattractant of vascular endothelial cells, and the inclusion and protection of growth factors.

The optimum technique was used in this work to decellularize the human allograft dermis product, and the procedure was verified using histological staining. The outcomes showed that this treatment’s removal of the epidermis was advantageous for a future procedure to eliminate cells from the dermal structure. ADM product appears to have a suitable potential as a substitute in wound healing based on overcoming the rejection of the allograft product with cells.

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