Combinatorial
Demineralized bone matrix (DBM) putty is a highly specialized bone graft material that has emerged as a valuable tool in the surgical management of bone defects. Derived from human or animal bone that has been processed to remove its mineral components, DBM putty presents a soft, malleable scaffold richly endowed with osteoconductive and osteoinductive properties. These properties enable DBM putty to serve as a platform for bone cell attachment, proliferation, and differentiation, fostering the regeneration of new bone tissue.
DBM putty offers a range of advantages over traditional autografts (bone grafts harvested from the patient’s own body) and allografts (bone grafts sourced from cadavers). Its osteoconductive nature allows it to seamlessly integrate with the surrounding bone, while its osteoinductive capacity stimulates the production of bone-forming proteins, accelerating the healing process.
The biocompatible carrier in which DBM putty is incorporated plays a crucial role in its moldable and easy-to-form nature. This carrier, typically a combination of collagen and alginate, provides the putty with its desired consistency, allowing surgeons to precisely shape and contour it to fill bone voids of various sizes and configurations. The carrier also contributes to the overall bioactivity of DBM putty, enhancing its ability to promote bone regeneration.